Rafael Nadal’s bid for a men’s-record 21st Grand Slam title has ended with a five-set loss to Stefanos Tsitsipas in the Australian Open quarterfinals. 

It is only the second time in Nadal’s career he has lost a Grand Slam match after taking the opening two sets. 

He went ahead rather easily against Tsitsipas to run his streak of consecutive sets won at major tournaments to 35. 

But a surprisingly poor tiebreaker by Nadal helped give the third set to Tsitsipas and begin the epic comeback. 

Now the 22-year-old from Greece will try to reach his first major final by beating Daniil Medvedev on Friday.