Never underestimate your friendly neighborhood Spider-Man, even with a mutating virus afoot. Despite rising concerns over the omicron variant, “Spider-Man: No Way Home” not only shattered pandemic-era box office records; it became the third best opening of all time behind “Avengers: Endgame” ($357.1 million) and “Avengers: Infinity War” ($257.7 million).

The Sony and Marvel blockbuster grossed a stunning $253 million in ticket sales from 4,325 North American locations, according to studio estimates on Sunday, also setting a record for the month of December. The web-slinger’s success couldn’t have come sooner for a movie business that has had a rollercoaster 2021 and could be headed for a difficult start to 2022 as the o micron variant of the coronavirus forces more and more event cancellations.

“This weekend’s historic ‘Spider-Man: No Way Home’ results, from all over the world and in the face of many challenges, reaffirm the unmatched cultural impact that exclusive theatrical films can have when they are made and marketed with vision and resolve,” said Tom Rothman, Sony Pictures Chairman and CEO, in a statement. “All of us at Sony Pictures are deeply grateful to the fabulous talent, both in front of and behind the camera, that produced such a landmark film.”