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Research: More physical activity needed as you grow older

2021 Nov 24, 13:07,

Everyone knows that physical activity is very important to have a healthy body. It not only keeps your muscle and joints strong but also fights against certain diseases.

However, as we age, we tend to lessen our physical activity and rest more, which, according to research, is wrong for our health.

The findings of this study have been published in the 'PNAS Journal'.

A team of evolutionary biologists and biomedical researchers from Harvard were taking a run at it (sometimes literally). The work laid out evolutionary and biomedical evidence showing that humans, who evolved to live many decades after they stopped reproducing, also evolved to be relatively active in their later years.

The researchers said that physical activity later in life shifted energy away from processes that compromised health and toward mechanisms in the body that extended it. They hypothesized that humans evolved to remain physically active as they age -- and in doing so allocated energy to physiological processes that slowed the body's gradual deterioration over the years. This guarded against chronic illnesses such as cardiovascular disease, type 2 diabetes, and even some cancers.

"It's a widespread idea in Western societies that as we get older, it's normal to slow down, do less, and retire," said Harvard evolutionary biologist Daniel E. Lieberman, the paper's lead author.

"Our message is the reverse: As we get older, it becomes even more important to stay physically active," he added

The research team, which included Aaron Baggish and I-Min Lee from Harvard Medical School, believed the paper is the first detailed evolutionary explanation for why lack of physical activity as humans aged increased disease risk and reduced longevity.

Baggish, 47, who also served as team cardiologist for the New England Patriots and U.S. Soccer, and Lieberman, 57, are long-time running buddies and often discussed the ideas that went into the paper during 5-to-10-mile morning runs.

The study used humans' ape cousins as a jumping-off point. The researchers pointed out that apes, which usually live for only about 35 to 40 years in the wild and rarely survived past menopause, are considerably less active than most humans, suggesting that there was a selection in human evolution not just to live longer but also to be more physically active.

"We evolved basically from couch potatoes," said Lieberman, who has twice observed wild chimpanzees in Tanzania and been surprised by how much of their day is spent "sitting on their butts, digesting."

This is especially jarring when contrasted against contemporary hunter-gatherers, who on average spend about 135 minutes of moderate to vigorous physical activity a day. That level of movement -- about six to ten times more than average Americans -- may be one of the keys to why hunter-gatherers who survive childhood tended to live about seven decades, approximately 20 years past the age at which humans generally stopped having children. Fossil evidence indicated that these extended life spans were common 40,000 years ago, contrary to the belief that human life spans until recently were short.

The team emphasized that the key health benefit of physical activity is to extend the human health span, which is defined as the years of life spent in good health.

Researchers examined two pathways by which lifelong physical activity reallocated energy to improve health. The first involved dealing with excess energy away from potentially harmful mechanisms, like excess fat storage. The team also identified how physical activity allocated energy to repair and maintenance processes. The paper showed that besides burning calories, physical activity is physiologically stressful, causing damage to the body at the molecular, cellular, and tissue levels. The body's response to this damage, however, is essential to build back stronger.

This included repairing tears in muscle fibers, repairing cartilage damage, and healing microfractures. The response also caused the release of exercise-related antioxidants and anti-inflammatories and enhanced blood flow. In the absence of physical activity, these responses are activated less. The cellular and DNA repair processes have been shown to lower the risk of diabetes, obesity, cancer, osteoporosis, Alzheimer's, and depression.

"The key take-home point is that because we evolved to be active throughout our lives, our bodies need physical activity to age well. In the past, daily physical activity was necessary in order to survive, but today we have to choose to exercise, that is do voluntary physical activity for the sake of health and fitness," Lieberman said.

The research team, which included graduate students Timothy Kistner and Daniel Richard, hope the study makes that message harder to ignore.

Physical activity levels had been decreasing worldwide as machines and technology replace human labor. A recent study from Lieberman's lab showed that Americans are engaging in less physical activity than they did 200 years ago.

The researchers' advice? Get out of your chair and get in some exercise.

"The key is to do something, and to try to make it enjoyable so you'll keep doing it," Lieberman said.

"The good news is that you don't need to be as active as a hunter-gatherer. Even small amounts of physical activity -- just 10 or 20 minutes a day -- substantially lower your risk of mortality." Lieberman added.


study Research age disease illness Exercise physical fitness health immunity technology American USA Evolution biology medicine
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