Researchers: COVID vaccines do not disrupt pregnancy

One barrier to vaccine acceptance is the concern that vaccination might disrupt pregnancy, but a recent study asserts it does not have any risk related to that.

The findings were reported by the Centers for Disease Control and Prevention (CDC).

Pregnant people who contract COVID-19 have an increased risk of disease severity and death, yet only 31 per cent of pregnant people in the United States had received vaccines as of September 2021.

A Yale co-led study, which looked at more than 40,000 pregnant individuals, adds new evidence supporting the safety of COVID-19 vaccination during pregnancy.

The study found COVID-19 vaccination during pregnancy was not associated with preterm birth or small-for-gestational-age (SGA) when comparing vaccinated with unvaccinated pregnant people.

The trimester when the vaccination was received and the number of COVID-19 vaccine doses received was also not associated with increased risk of preterm birth or SGA, the researchers found.

Preterm birth (in which babies are delivered earlier than 37 weeks) and SGA (in which babies are delivered smaller in size than normal for the gestational age) have been associated with a higher risk for infant death and disability. For the new study, the authors used data from eight health care organizations participating in Vaccine Safety Datalink -- a project established by the CDC to monitor vaccine safety -- to investigate the risk for preterm birth or SGA among vaccinated and unvaccinated pregnant women aged 16 to 49 years.

Among those included in the study, 10,064 individuals, or nearly 22 per cent, received at least one COVID-19 vaccine dose during pregnancy, researchers said. Most (98.3 per cent) received vaccination during their second or third trimester; the rest (1.7 per cent) received it during their first trimester of pregnancy. Almost 96 per cent of those vaccinated received an mRNA vaccine developed by Pfizer-BioNTech or Moderna.

Till date, a few studies have described outcomes among live births following COVID-19 vaccination in pregnancy, the researchers say. The new findings add to the evidence that COVID-19 vaccination is safe during pregnancy.

Research into the drivers behind low vaccine acceptance among pregnant people has found that the most common concerns have been a lack of information about COVID-19 vaccine safety in pregnant people and potential harm to the fetus. The results of this study speak to both, said Heather Lipkind, associate professor of obstetrics, gynaecology, and reproductive sciences at the Yale School of Medicine and lead author of the study.

"Getting vaccinated against COVID-19 is important for preventing severe illness in pregnant people," said Lipkind. "With the increasing rates of COVID-19 in our community, we are encouraging pregnant people to get vaccinated."

Pregnant individuals, in addition to seeing an increased risk of severe disease and death compared with non-pregnant people, are more likely to require admission into the intensive care unit, invasive ventilation, and machine-assisted blood oxygenation.

The CDC and the American College of Obstetricians and Gynecologists recommend the COVID-19 vaccine for people who are pregnant, breastfeeding, trying to get pregnant, or might become pregnant in the future.