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Study aims to understand muscle fatigue in older adults

2021 Aug 25, 12:33, Washington

Older adults on a walk or hike, or just going about their daily routines, seem to experience greater fatigue than their younger counterparts. Such fatigue may ultimately affect their ability to participate in activities that are meaningful to them and help keep them healthy.

A University of Massachusetts Amherst team of scientists in the School of Public Health and Health Sciences is focused on understanding how muscle fatigue and changes in gait affect the ability of people in their 70s and 80s to remain active.

With a USD 1.8 million grant from the National Institutes of Health's (NIH) National Institute on Aging, biomechanical engineer Katherine Boyer will lead the study, which has started to recruit participants in Western Massachusetts.

"We have worked for many years to understand how age impacts how you move and how physical activity levels or lifestyle factors may influence how quickly or slowly you change to an 'older' movement pattern," said Boyer, whose team includes kinesiologists Jane Kent and Stuart Chipkin, and biostatistician Carol Bigelow, as well as movement scientist Brian Umberger, formerly of UMass Amherst and now a professor at the University of Michigan.

"This can impact your mobility, your ability to accomplish activities of daily living. We also think that as you move differently it may require more energy," Boyer added.

To assess mobility, they will use a new metric called fatigability that offers a better performance comparison among different age groups. "Fatigability is a measurement that allows us to assess an individual's change in performance and their reports of perceived effort in response to a standardized bout of activity," Boyer said. "So now we have something that's equal for all age groups that we can use in order to quantify fatigue."

In her Muscle Physiology Lab, Kent developed a 30-minute treadmill protocol to induce muscle fatigue. Boyer and colleagues in Boyer's Musculoskeletal and Orthopedic Biomechanics Lab then measure the mechanics of movement using gait analysis. "We quantify muscle fatigue on an isokinetic dynamometer; it's a little bit like a knee extension or flexion machine you'd find in the gym except we have sensors to measure how strong your quadriceps and calf muscles are and how that changes," Boyer explained.

The scientists are recruiting four groups of 15 men and 15 women each: sedentary young adults (ages 30-40) and three groups of 70- to 80-year-olds (healthy, mobility-impaired, and active). Except for the active group, the other participants will be "relatively sedentary," similar to the general US population.

"This combination of groups will allow us to evaluate the independent effects of age, physical activity, and mobility impairment, and test for sex effects," Boyer says.

In his Locomotion Research Laboratory, Umberger will conduct computer simulations of walking based on models representing the four groups of study participants that will provide a mechanistic understanding of the muscular basis for the gait adaptations and their consequences.

"The strength of our work is that we'll have both a full experimental study and the computer simulations that will accompany it on the same individuals with the same outcome measures," Boyer said. "So we'll start to understand how and why these things might be changing, which should help us inform an intervention at a later stage."

Currently, activity guidelines for older adults are the same as for younger ones - at least 150 minutes per week of moderate-intensity activity or exercise. It may be, however, that older adults have different needs or specific movements that would be beneficial that this research will begin to inform.

"Older people aren't getting lazy. The fatigue is not in their head. Physiological changes are happening that make everyday activities feel more difficult. Our primary goal is to understand how this happens," Boyer said. 


Stamina Older adults health Muscle Fatigue
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