A new study has revealed that 44 per cent of hospitalised children who tested or were presumed positive for SARS-CoV-2, developed neurological symptoms, and were more likely to require intensive care than their peers who didn't experience such symptoms.
The study was led by a pediatrician-scientist at UPMC and the University of Pittsburgh School of Medicine and was published in the journal 'Pediatric Neurology'.
The most common neurologic symptoms in the children were headache and altered mental status, known as acute encephalopathy. These preliminary findings have been the first insights from the pediatric arm of GCS-NeuroCOVID, an international, multi-center consortium aiming to understand how COVID-19 affects the brain and nervous system.
"The SARS-CoV-2 virus can affect pediatric patients in different ways: It can cause acute disease, where symptomatic illness comes on soon after infection, or children may develop an inflammatory condition called MIS-C weeks after clearing the virus," said lead author Ericka Fink, M.D., pediatric intensivist at UPMC Children's Hospital of Pittsburgh, and associate professor of critical care medicine and pediatrics at Pitt. "One of the consortium's big questions was whether neurological manifestations are similar or different in pediatric patients, depending on which of these two conditions they have," he said.
To answer this question, the researchers recruited 30 pediatric critical care centers around the world. Of 1,493 hospitalized children, 1,278, or 86 per cent, were diagnosed with acute SARS-CoV-2; 215 children, or 14 per cent, were diagnosed with MIS-C, or multisystem inflammatory syndrome in children, which typically appeared several weeks after clearing the virus and was characterized by fever, inflammation and organ dysfunction.
The most common neurologic manifestations linked with acute COVID-19 were headache, acute encephalopathy and seizures, while youths with MIS-C most often had headache, acute encephalopathy and dizziness. Rarer symptoms of both conditions included loss of smell, vision impairment, stroke and psychosis.
"Thankfully, mortality rates in children are low for both acute SARS-CoV-2 and MIS-C," said Fink. "But this study shows that the frequency of neurological manifestations is high--and it may actually be higher than what we found because these symptoms are not always documented in the medical record or assessable. For example, we can't know if a baby is having a headache."
The analysis showed that neurological manifestations were more common in kids with MIS-C compared to those with acute SARS-CoV-2, and children with MIS-C were more likely than those with acute illness to have two or more neurologic manifestations.
According to Fink, the team recently launched a follow-up study to determine whether acute SARS-CoV-2 and MIS-C--with or without neurologic manifestations--had any lasting effects on children's health and quality of life after discharge from hospital.
"Another long-term goal of this study is to build a database that tracks neurological manifestations over time--not just for SARS-CoV-2, but for other types of infections as well," she added. "Some countries have excellent databases that allow them to easily track and compare children who are hospitalized, but we don't have such a resource in the US."
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