Thursday May 30, 2024
Thursday May 30, 2024

Covid-19 virus fastly evolving in white-tailed deer: Study


Nepalnews
ANI
2023 Aug 28, 17:59, Ohio [US]

 According to recent research, the virus that causes Covid-19 has infected white-tailed deer all around Ohio. The study's findings also demonstrate that viral variations change in deer almost three times quicker than they do in people.

Between November 2021 and March 2022, researchers collected 1,522 nasal swabs from deer that were allowed to roam freely in 83 of the state's 88 counties. More than 10 per cent of the samples tested positive for the SARS-CoV-2 virus, and in 59 per cent of the counties where testing was conducted, at least one positive case was discovered.

Genomic analysis showed that at least 30 infections in deer had been introduced by humans – a figure that surprised the research team.

“We generally talk about interspecies transmission as a rare event, but this wasn’t a huge sampling, and we’re able to document 30 spillovers. It seems to be moving between people and animals quite easily,” said Andrew Bowman, associate professor of veterinary preventive medicine at The Ohio State University and co-senior author of the study.

“And the evidence is growing that humans can get it from deer – which isn’t radically surprising. It’s probably not a one-way pipeline.”

The combined findings suggest that the white-tailed deer species is a reservoir for SARS-CoV-2 that enables continuing mutation, and that the virus’s circulation in deer could lead to its spread to other wildlife and livestock.

The study is published in Nature Communications.

Bowman and colleagues previously reported detection of SARS-CoV-2 infections in white-tailed deer in nine Ohio locations in December 2021, and are continuing to monitor deer for infection by more recent variants.

“We expanded across Ohio to see if this was a localized problem – and we find it in lots of places, so it’s not just a localized event,” Bowman said. “Some of the thought back then was that maybe it’s just in urban deer because they’re in closer contact with people. But in rural parts of the state, we’re finding plenty of positive deer.”

Beyond the detection of active infections, researchers also found through blood samples containing antibodies – indicating previous exposure to the virus – that an estimated 23.5 per cent of deer in Ohio had been infected at one time or another.

The 80 whole-genome sequences obtained from the collected samples represented groups of viral variants: the highly contagious delta variant, the predominant human strain in the United States in the early fall of 2021 that accounted for almost 90 per cent of the sequences, and alpha, the first named variant of concern that had circulated in humans in the spring of 2021.

The analysis revealed that the genetic composition of delta variants in deer matched dominant lineages found in humans at the time, pointing to the spillover events and that deer-to-deer transmission followed in clusters, some spanning multiple counties.

“There’s probably a timing component to what we found – we were near the end of a delta peak in humans, and then we see a lot of delta in deer,” Bowman said. “But we were well past the last alpha detection in humans. So the idea that deer are holding onto lineages that have since gone extinct in humans is something we were worried about.”

The study did suggest that COVID-19 vaccination is likely to help protect people against severe disease in the event of a spillover back to humans. An analysis of the effects of deer variants on Siberian hamsters, an animal model for SARS-CoV-2 studies, showed that vaccinated hamsters did not get as sick from infection as unvaccinated animals.

That said, the variants circulating in deer are expected to continue to change. An investigation of the mutations found in the samples provided evidence of more rapid evolution of both alpha and delta variants in deer compared to humans.

“Not only are deer getting infected with and maintaining SARS-CoV-2, but the rate of change is accelerated in deer – potentially away from what has infected humans,” Bowman said.

How the virus is transmitted from humans to white-tailed deer remains a mystery. And so far, even with about 30 million free-ranging deer in the U.S., no substantial outbreaks of deer-origin strains have occurred in humans.

Circulation among animals, however, remains highly likely. Bowman noted that about 70 per cent of free-ranging deer in Ohio have not been infected or exposed to the virus, “so that’s a large body of naive animals that the virus could spread through rather uninhibited.”

“Having that animal host in play creates things we need to watch out for,” he said. “If this trajectory continues for years and we have a virus that becomes deer-adapted, then does that become the pathway into other animal hosts, wildlife or domestic? We just don’t know.”

This work was supported by the National Institute of Allergy and Infectious Diseases and Ohio State’s Infectious Diseases Institute.



READ ALSO:

covid-19 virus white-tailed Deer SARS-CoV-2 virus
Nepal's First Online News Portal
Published by Nepalnews Pvt Ltd
Editor: Raju Silwal
Information Department Registration No. 1505 / 076-77

Contact

Kathmandu, Nepal,


Newsroom
##

E-mail
[email protected]

Terms of Use Disclaimer
© NepalNews. 2021 All rights reserved. | Nepal's First News Portal